2017 Alzheimer Award Goes to Shi-Jiang Li for Developing CARE Index

2017 Alzheimer Award Goes to Shi-Jiang Li for Developing CARE Index
Prof. Shi-Jiang Li, PhD, is the recipient of the 2017 Alzheimer Award granted every year by the associate editors of the Journal of Alzheimer’s Disease (JAD). Li was singled out for his and his team's outstanding work published in the journal about a new index called the “characterizing Alzheimer's disease risk events” (CARE), which determines the severity of the disease in a patient and facilitates personalized treatment. The winning study, "Staging Alzheimer's Disease Risk by Sequencing Brain Function and Structure, Cerebrospinal Fluid, and Cognition Biomarkers," was published in the Journal of Alzheimer’s Disease last year. “The CARE index significantly correlates with disease severity and exhibits high reliability,” the authors of the study reported. Li, a professor of biophysics, radiology, and psychiatry and behavioral medicine at the Medical College of Wisconsin, and his colleagues developed the CARE index to identify the risks associated with stages of Alzheimer's disease, and to measure disease severity in individuals. The index is based on 10 biomarkers measured by analyzing neuroimaging results, cerebrospinal fluid (the fluid that bathes the brain and spinal cord), and cognitive performance. "The CARE index constructed the main framework for biology-based [Alzheimer's] stages and demonstrated that clinically diagnosed mild cognitive impairment subjects are biologically heterogeneous and are distributed across the [Alzheimer's disease] continuum," Li said in a press release. "We believe the CARE in
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