Chronic Lack of Sleep May Raise Risk of Alzheimer’s Disease, Study Suggests

Chronic Lack of Sleep May Raise Risk of Alzheimer’s Disease, Study Suggests
A poor night’s sleep may increase the levels of proteins associated with Alzheimer’s disease, say researchers, noting that their findings may be especially important for people with chronic sleep disorders. The study by scientists at Stanford University, Washington University School of Medicine in St. Louis and Radboud University Medical Centre in the Netherlands, “Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels,” appeared in the journal Brain. "We showed that poor sleep is associated with higher levels of two Alzheimer's-associated proteins," Dr. David M. Holtzman and the study's senior researcher, said in a news release. "We think that perhaps chronic poor sleep during middle age may increase the risk of Alzheimer's later in life." Previous studies had shown that lack of sleep increases the production of beta-amyloid, suggesting that patients who suffer chronic sleep deprivation may be at high risk of Alzheimer's. However, researchers did not know exactly what aspect of sleep is associated with beta-amyloid levels and other disease biomarkers. To find out, the study enrolled 17 healthy adults (aged 35 to 65 years) with no sleep or cognitive disorders. Researchers analyzed brain wave activity during a polysomnogram, which uses a wrist monitor to record a person’s sleep. After five or more successive nights wearing the monitor, participants were invited to spend a night in a sleep room designed for the study. Half of them, however, were assigned to have their sleep disturbed while a mo
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  1. larry junis says:

    It seems you are damned if you do and damned if you don’t. If you take sleep meds they can damage your brain and if you don’t and can’t sleep, this damages your brain also! A doctor from a sleep clinic prescribed Zolpidem(generic for Ambien). I saw a neurologist and he told me to stop taking it and would not recommend any sleep meds.

    • Tim Bossie says:

      That is usually the way things go. One doctor says one thing… and other says they are wrong. You have to trust your doctors, but also be your own advocate and do what works best for you.

    • Darryl says:

      When you take sleep meds a lot of times you do not get into REM level sleep, which is a big problem because when you are in REM level sleep Cerebral Spinal Fluid comes out and it pushes the plaque Amyloid Beta into your blood stream. Amyloid Beta is protein that is known for causing Alzheimer’s.

      If you cannot sleep make sure that your nutrients are not depleted magnesium, vitamin D & K2, calcium, potassium, zinc and melatonin, because if any of these are low you will not sleep well.

      The reason you might be low on these nutrients can be if you are taking just about any medication to eating too much sugar

      E.G. If you are on an antidepressant I would bet you that
      – Your PCP did not check your vitamin levels
      – Your PCP did not tell you that you need to take the medication with protein
      – Your PCP did not tell you the nutrients that get depleted by the medications
      – Your pharmacists does not tell you the nutrients that get depleted by the medications
      – your insurance company probably would not have paid for the test to check your nutrient levels
      – The pharmaceutical company does not tell you the nutrients that get depleted by their medications on the sheet with all the contraindications and warnings either.

      Nutrients that are depleted by antidepressants
      Coenzyme Q10.
      B vitamins, including Folate, B2, B6 and B12.

  2. Sharon Gronow says:

    The only way for females to get some sleep with young children and babies is to co-sleep and breast feed. But they say not to do that. Can you imagine what its like to live for years getting up to babies and kids without a decent nights sleep? Then, theres menopause with hot flashes and restless legs for maybe 10 years. No wonder dementia affects more men than women. Uugh😑

  3. Prof. A Kamil Pinarci PhDq, MSc. says:

    There are many solutions to sleep well without heavy drugs. First one exercise or even light walk for 20 minutes, second warm milk and stop thinking the daily problems which is good for your heart and brain, and most important take a garlic pill which lowers your blood pressure and gives you a wonderful sleep. But if you have major problems with sleeping your doctor may advise a helpful medicine

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