Inhibiting HDAC2 Enzyme May Stop Memory Loss

Inhibiting HDAC2 Enzyme May Stop Memory Loss
A research team from MIT has found a way to reverse memory loss in mice, which may lead to new treatments for patients with Alzheimer's disease. The findings were reported in a study titled “The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons” and published in the journal Cell Reports. The method focuses on the interactions of the SP3 gene with an enzyme named HDAC2, which can turn genes off that are essential for creating new memories. This process contributes to the formation of a genetic blockade in the brains of patients with Alzheimer's disease and leads to cognitive decline. “If we can remove the blockade by inhibiting HDAC2 activity or reducing HDAC2 levels, then we can remove the blockade and restore expression of all these genes necessary for learning and memory,” explained Li-Huei Tsai, director of MIT’s Picower Institute for Learning and Memory and the study’s lead author, in a press release. Researchers had previously known that the enzyme prevented transcription of memory-linked genes, such as those responsible for synaptic plasticity. Moreover, it was augmented in both the brains of patients with Alzheimer's disease and in multiple mouse models of the disease. Although HDAC2 inhibitors prevent memory loss in animal models, they also affect other HDAC family members, which causes side effects. To overcome this problem, the team looked for specific partners that the enzyme requires for gene silencing, which led them to a gene called Sp3. This gene helps r
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3 comments

    • Tim Bossie says:

      Thank you for the question Susan. We wish we could give you an answer, but we are monitoring this and will update as soon as we know more information.

  1. Lic. phil. Irene Zbinden-Birchmeier says:

    Dear Mr. Bossie

    I have the same question like Susan Finger. My husband suffers under loosing memory. And I am very interesting to know when this compound is produced for human beings. I hope for Aducanumab or other compounds so my husband can live a better life. If science points in Switzerland are available for HDAC2, please let my know.

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