Energy Shortage in Brain’s Immune Cells Might Explain Alzheimer’s Risk with TREM2 Mutations

Energy Shortage in Brain’s Immune Cells Might Explain Alzheimer’s Risk with TREM2 Mutations
A lack of energy in brain cells called microglia might explain why people with mutations in the TREM2 gene are more likely to develop Alzheimer's disease, according to a mouse study that showed exhausted microglia lacked the capacity to confine amyloid plaques. By restoring the energy levels in these cells, it might be possible to treat people with this specific genetic makeup. But researchers say their findings might have even wider implications. If it is also possible to make microglia more energized in people with normal brain function, it might turn out to benefit all Alzheimer's patients, the team at Washington University School of Medicine (WUSC) suggested. “Everybody has some plaques, but the activity of these cells affects ho
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