Hormone Klotho Boosts Cognition in Mouse Models of Alzheimer’s and Parkinson’s, Study Shows

Hormone Klotho Boosts Cognition in Mouse Models of Alzheimer’s and Parkinson’s, Study Shows
The naturally occurring hormone klotho improved cognition in mouse models of Alzheimer's and Parkinson's disease, according to a University of California medical center study. Researchers said the findings could lead to new therapies for the neurological disorders. The study that the team published in Cell Reports was titled Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice.” Klotho, produced in the brain and kidneys, helps regulate several processes that affect life span. These include the production of other hormones. Scientists know that levels of klotho decrease over time. They also know that chronic stress and neurodegenerative diseases can decrease the hormone's levels. Boosting levels of klotho improved nerve-cell resilience and cognition in mice and humans, regardless of age, previous studies showed. The University of California at San Francisco researchers decided to see if klotho could improve cognition in mice with neurodegenerative disorders. They injected a fragment of the protein into mice with Alzheimer's and Parkinson's. Then they tested the animals' cognition, including their learning and memory. Four days of klotho significantly improved young mice's cognition, an effect that was sustained for more than two weeks. Older mice showed cognitive improvement only two days after receiving a single dose of the protein. Klotho also improved cognitive and movement impairment in mouse models of neurodegenerative disease. Researchers injected the animals with toxic alpha-synuclein protein to c
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