Targeting ApoE in Brain Alone May Lead to Alzheimer’s Treatment, Researchers Say

Targeting ApoE in Brain Alone May Lead to Alzheimer’s Treatment, Researchers Say
Scientists are coming closer to understanding how the gene variant apolipoprotein E4 (ApoE4) raises the risk of Alzheimer’s disease. Blocking ApoE4 — one of several variants of the ApoE gene — in the brain may prevent cell death and inflammation and lead to a treatment for Alzheimer’s, concludes a study, “ApoE4 markedly exacerbates tau-mediated neurodegeneration in a

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2 comments

  1. Linda Grishman says:

    Sounds promising. I have early stage Alzheimers. It started with my maternal aunt decades ago; then my Mom, then my cousin (my aunt’s daughter) and then my sister. My sister was 12 years my senior and much younger than my cousin.
    I had decided to be proactive and saw several neurologists in New York City. At that time my memory was fine. I have been on Aricept for a number of years; the lowest dosage, but I increased it by taking an additional half pill. Suddenly last winter 2016, I had a few frightening episodes; although I only got lost once (took a wrong turn on my way back from Costco). It wasn’t anything major. And I did make it home safely …albeit about 20 minutes later than usual. It was just when time change happened and the darkness was what confused me. It was certainly very alarming and upsetting. I hope you will reply to this comment. Linda

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