Lost Sense of Smell May Signal Early Alzheimer’s Disease, Mouse Study Suggests

Lost Sense of Smell May Signal Early Alzheimer’s Disease, Mouse Study Suggests
Clumps of the Alzheimer's-related protein amyloid-beta in nerves around organs related to smell may explain why people in the early stages of the disease lose their ability to detect odors, a study reports. Researchers at the Daegu Gyeungbuk Institute of Science and Technology in South Korea also discovered that loss of the ability to smell occurs before cognitive loss, at least in an animal model of the disease. Their discoveries add to efforts to identify factors that doctors could use to determine who is likely to develop Alzheimer's. They also pave the way for similar studies in humans. The study appeared in the journal Cell Death & Disease. Its title was “Differential spatial expression of peripheral olfactory neuron-derived BACE1 induces olfactory impairment by region-specific accumulation of β-amyloid oligomer.” "We have discovered an important clue to predict the onset of Alzheimer's disease in the early stage by identifying a mechanism of beta-amyloid expression in the initial stage of Alzheimer's that was unknown until now," Moon Cheil, a professor in the institute's Department of Brain and Cognitive Sciences, said in a press release. He was the senior author of the study. To reach the conclusion that there is a link between beta-amyloid clumping and loss of smell, the researchers studied mice carrying a mutation that mak
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  1. John Menmuir says:

    My wife used to have a very good sense of smell but Alzheimer’s has robbed her completely of this sense. You don’t need mice to prove it!

  2. Ar Hue says:

    article left me very angry, because it never cites what odors can be used as a test. Pine? Lemon oil? Mint? Dog shit? What????? Just say it, damn it! Worthless article.

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