Menopause May Raise Alzheimer’s Risk Though Metabolic Changes in Brain, Study Says

Menopause May Raise Alzheimer’s Risk Though Metabolic Changes in Brain, Study Says
Menopause triggers numerous changes in a woman's body — and, apparently, metabolic changes in the brain as well that puts middle-age women at greater risk of Alzheimer's disease, a study reports. This finding provides new insights into why women have a higher incidence of this neurological disease, even when a generally longer lifespan accounted. It also may promote new ways of evaluating these people to detect early signs of Alzheimer's and try to prevent its progression. The study, titled “Perimenopause and emergence of an Alzheimer’s bioenergetic phenotype in brain and periphery,” was conducted by researchers at Weill Cornell Medicine and the University of Arizona Health Sciences and published in the journal PLOS One. "This study suggests there may be a critical window of opportunity, when women are in their 40s and 50s, to detect metabolic signs of higher Alzheimer's risk and apply strategies to reduce that risk," Lisa Mosconi, an associate professor of neuroscience in neurology at Weill Cornell and the study's lead author, said in a news release. Researchers evaluated the bioenergetics status of the brains of 43 women, ages 40 to 60, who were clinically and cognitively healthy. With the use of positron emission tomography (PET) imaging, they could evaluate the consumption of glucose, the main energy source used by cells, in the brain. Results showed that women who had undergone menopause (15 wo
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