Potential Therapy, CT1812, Seen as Safe and Able to Target Disease Markers, Cognition Reports

Potential Therapy, CT1812, Seen as Safe and Able to Target Disease Markers, Cognition Reports
Cognition Therapeutics’ lead drug candidate for mild-to-moderate Alzheimer’s disease (AD), CT1812, was shown to be well-tolerated and to lower brain levels of proteins involved in the disease, the company reports. These results, part of a Phase 1b/2a clinical trial, were given in an oral presentation at the recent 10th Clinical Trials on Alzheimer’s Disease (CTAD) meeting

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One comment

  1. william whitfield says:

    Speaking for the millions of my fellow sufferers and our loved ones who currently – barring an earlier demise – face without hope a lengthy, potentially decade or longer decline involving a horrific loss of mind and spirit before ultimately the body also dies, I have a few related questions I hope someone will be able and willing to answer.

    First, given the incredible >100 year history of Alzheimer’s dedicated medical researchers’ continuing failure to discover/develop even a single disease altering Alz treatment prior to this CT1812 potential one, just how long must even the currently defined ‘Fast Track’ designation still be required to run? Long enough for some (presumed) broadly applicable statistical measure of efficacy is met prior to allowing the currently doomed the same right to participate in a chance for life as have the trial participants? Or if so, shouldn’t this encouraging CT1812 development offer the community a chance to re-valuate existing ‘Fast Track’ criteria with a view towards identifying varying degrees of ‘fast track’ which can far better reflect any significantly varying circumstance or characteristic of a potential ‘fast track’ candidate?

    In any case, lacking an early major change to existing ‘Fast Track’ criteria by the FDA, certainly thousands and perhaps millions of us will continue to suffer and die without being afforded a chance to accept the same risks of failure or joys of success that roughly half of the selected trial participants will have.

    Finally, this also brings up the question of what if any laws have our legislatures enacted that gives our government (the FDA) the right to withhold from providers the ability to prescribe supervised access to almost any treatment or experimental drug that meets the existing requirements for an NIH approved trial participation? If none, shouldn’t there be, or to the extent such laws may exist, have they been challenged and found judicially to be in compliance with our Constitution?

    bw

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