Potential Therapy, CT1812, Seen as Safe and Able to Target Disease Markers, Cognition Reports

Potential Therapy, CT1812, Seen as Safe and Able to Target Disease Markers, Cognition Reports
Cognition Therapeutics’ lead drug candidate for mild-to-moderate Alzheimer’s disease (AD), CT1812, was shown to be well-tolerated and to lower brain levels of proteins involved in the disease, the company reports. These results, part of a Phase 1b/2a clinical trial, were given in an oral presentation at the recent 10th Clinical Trials on Alzheimer's Disease (CTAD) meeting in Boston by Lon Schneider, MD, a professor at the USC Keck School of Medicine,  and in a poster presentation by a company executive. An abstract on the Schneider's talk is titled “The Anti-Aβ Oligomer Drug CT1812 for Alzheimer’s: Phase 1b/2a Safety Trial Outcomes.” CT1812 is a small molecule that has shown an ability to effectively penetrate into the brain. Once there, it works to displace the amyloid-beta (Aβ) oligomers from their binding sites (or receptors) on neuron cells in the brain, and dispel the oligomers from the cerebrospinal fluid (CSF). Aβ oligomers are thought to play a major role in Alzheimer’s disease pathology, and CT1812 has demonstrated an ability to stop memory loss in animal models of AD. The clinical trial (NCT02907567) was conducted to determine the safety and pharmacokinetics (the drug's behavior in the body) of CT1812. It enrolled 19 people with mild-to-moderate AD, and treated them with either placebo or one of three doses of CT1812 (90, 280 and 560 mg) for 28 days. Levels of AD protei
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