Anavex Highlights Role of Sigma-1 Brain Receptor in Alzheimer’s Development

Anavex Highlights Role of Sigma-1 Brain Receptor in Alzheimer’s Development
Anavex Life Sciences has published a study demonstrating the sigma-1 receptor's role in Alzheimer’s disease. The data contained in it supports the New York-based company's development of compounds stimulating this receptor as a way of treating the illness. The study, “Sigma-1 Receptor Agonists Induce Oxidative Stress in Mitochondria and Enhance Complex I Activity in Physiological Condition but Protect Against Pathological Oxidative Stress,” appeared in the journal Neurotoxicity Research. It showed that sigma-1 boosting compounds act as antioxidants and protect energy-making structures called mitochondria in conditions such as Alzheimer’s. Meanwhile, another study, “Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the σ1 receptor,” published in the journal Behavioural Brain Research, showed that a lack of sigma-1 worsens toxicity brought on by amyloid proteins. "Both findings are consistent with the concept that sigma-1 receptor activity seems to be essential for cell survival under stress, with the ability to counter the different manifestations of Alzheimer's disease and other neurodegenerative pathologies," Dr. Tangui Maurice, senior author of both studies and a professor at the French scientific research institute INSERM, said in a
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