Diabetes Therapy Could Be Used to Treat Alzheimer’s, Study Reports

Diabetes Therapy Could Be Used to Treat Alzheimer’s, Study Reports
An approved treatment for diabetes may help people with Alzheimer’s, a study reports. The research, “Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease,” was published in the journal Brain Research. Many scientists have tried without success to develop Alzheimer's treatments over the past 15 years. This has prompted some to start investigating new approaches. Type 2 diabetes is a risk factor for Alzheimer's, most likely due to impaired insulin signaling in patients' brains. This has led to researchers looking at whether drugs that treat diabetes could also be used for Alzheimer's. Some scientists have focused on a triple receptor agonist that companies developed as a potential treatment for diabetes. This drug activates the receptors of the nerve cell growth factors GLP-1, GIP and glucagon in patients' brains, protecting against nerve cell degeneration. Researchers used a mouse model of Alzheimer's in their study. Mice which have this configuration demonstrate classic Alzheimer's symptoms, such as memory loss, loss of nerve signaling, chronic inflammation, loss of nerve cell production, and formation of harmful amyloid plaque in the brain. The scientists injected the mice with the receptor agonist once a day for two months, studying its ability to protect nerve cells as they went. A water maze test showed that the agonist significantly reversed the memory problems the mice were having. The drug also reduced cell-death-related signaling and increased levels of BDNF, a signal-protecting g
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