Servier and Treventis Teaming Up to Develop Therapies That Can Circumvent Protein Misfolding

Servier and Treventis Teaming Up to Develop Therapies That Can Circumvent Protein Misfolding
Servier and Treventis will work together on therapies that can circumvent the misfolded proteins involved in Alzheimer’s and other neurodegenerative diseases. The goal is to develop compounds that prevent the brain's accumulation of two faulty proteins associated with the disorders — amyloid beta and tau. Servier is an international pharmaceutical concern led by a non-profit foundation based in France. Treventis is a U.S. company that specializes in developing small molecules that can circumvent the misfolded proteins in the harmful versions of tau and amyloid beta. Under their agreement, Servier will cover the research costs and have worldwide rights to commercialize any compounds the partners develop. "We very much hope that this new collaboration will allow us to answer the huge unmet patient need for disease-modifying treatment of Alzheimer's disease, thanks to Treventis' unique and innovative technology," Christian de Bodinat, director of Servier’s Center of Therapeutic Innovation in Neuropsychiatry, said in a press release. "We are very excited to be part of one of the first programs employing a dual approach in this field." Developing small molecules that can prevent the production of faulty versions of both tau and amyloid beta is a major challenge because the two proteins misfold in different ways.Treventis scientists are dealing with the challenge by zeroing in on a binding site that the proteins have in common. "We
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