Researchers Abandon Idalopirdine as Alzheimer’s Treatment After Phase 3 Failures

Researchers Abandon Idalopirdine as Alzheimer’s Treatment After Phase 3 Failures
Another treatment has joined the long list of compounds that have failed to show effectiveness against Alzheimer’s disease. Three Phase 3 clinical trials showed that idalopirdine was unable to improve more than 2,500 patients' cognition. A Phase 2 trial suggesting that the treatment was effective has led to researchers speculating about the disconnect. But the bottom line is that the late-stage results have prompted scientists to agree that idalopirdine has no place in Alzheimer’s treatment, particularly since a similar compound — intepirdine — recently failed a Phase 3 trial. Researchers announced the findings in an article titled “Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease — Three Randomized Clinical Trials.” It appeared in the journal JAMA. The Phase 3 trials (NCT01955161, NCT02006641, and NCT02006654) tested idalopirdine as an add-on to treatment with cholinesterase inhibitors, including Aricept (donepezil), Exelon (rivastigmine), and Razadyne (galantamine). Idalopirdine — developed jointly by Lundbeck and Otsuka Pharmaceutical — was designed to treat Alzheimer's symptoms, and not alter t
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