Saving Brain Connections by Targeting Synaptic Proteins May Treat Alzheimer’s, Study Finds

Saving Brain Connections by Targeting Synaptic Proteins May Treat Alzheimer’s, Study Finds
Proteins in nerve cell synapses, which transmit signals between neurons, are abnormal in the brains of patients with Alzheimer’s disease and other dementias, Swedish researchers concluded after performing a large-scale analysis of synaptic proteins in patients’ brains. By studying these flaws, researchers could distinguish between Alzheimer’s patients and those with Parkinson’s disease dementia. A loss

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3 comments

  1. DANTE MARCIANI says:

    The issue here, is are these proteins the cause or a result of Alzheimer’s disease? While their value as markers seems to be high, the issue of being therapeutic targets would need confirmation that they are involved in causing the disease.

  2. From what I have studied, the protein (amyloid) is produced naturally in the body and serves a purpose in keeping the synapses from firing uncontrollably, so as to prevent events like epilepsy. Amyloid can cause its own problems if it is allowed to accumulate unchecked. So there are certain components such as microglia that clear away excess amyloid. For reasons not clearly understood, sometimes microglia fails to clear away excess amyloid, and some processes stimulate the production of abnormal amounts of amyloid. When amyloid is allowed to accumulate in the brain, it disrupts normal synaptic functions, and this is one of the hallmarks of Alzheimer’s Disease.

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