Carvedilol Failed to Improve Episodic Memory in Alzheimer’s Patients

Carvedilol Failed to Improve Episodic Memory in Alzheimer’s Patients
Results from a pilot Phase 4 clinical trial evaluating the potential benefit of a known blood pressure and heart failure treatment, carvedilol, in Alzheimer’s disease showed the medicine had no effect in the episodic memory of patients. However, carvedilol was able to prevent the increase of beta-amyloid levels in cerebrospinal fluid. Alzheimer’s disease is caused by abnormal and toxic accumulations of proteins, such as beta-amyloid and tau proteins, which interfere with the communication between nerve cells. Beta-amyloid peptide 42 (Abeta 42) is the most toxic form of beta-amyloid aggregates and is considered a primary driver for  developing the disease. Carvedilol, a beta-blocker, is an approved treatment for high blood pressure and heart failure. However, experiments in mouse models have suggested it interferes with the build-up of beta-amyloid aggregates in the brain, making it a potential therapy for Alzheimer’s disease. A randomized placebo-controlled pilot Phase 4 trial (NCT01354444) evaluated the effectiveness and safety of carvedilol in patients with early-stage Alzheimer’s disease. Its primary goal was episodic memory (memory regarding personal facts and experiences) measured through the Hopkins Verbal Learning Test (HVLT). The secondary goal was the effect of carvedilol treatment in the levels of beta-amyloid in the cerebrospinal fluid. Twenty-nine adult patients were enrolled at the trial site, the 
Subscribe or to access all post and page content.