#AAN2018 – PRIME Trial Data Show Long-term Benefits of Aducanumab in Early Alzheimer’s

#AAN2018 – PRIME Trial Data Show Long-term Benefits of Aducanumab in Early Alzheimer’s
Long-term use of BIIB037 (aducanumab) can prevent progression of Alzheimer’s in patients at early stages of the disease, according to results from the PRIME study. Biogen, maker of aducanumab, will present those results at the 2018 Annual Meeting of the American Academy of Neurology (AAN), April 21-27 in Los Angeles, California. The clinical effects of 24 and 36 months treatment with aducanumab will be presented in two studies, “Aducanumab titration dosing regimen: 24-month analysis from PRIME, a randomized, double-blind, placebo-controlled Phase 1b study in patients with prodromal or mild Alzheimer’s disease” and “Aducanumab 36-month data from PRIME: a randomized, double-blind, placebo- controlled Phase 1b study in patients with prodromal or mild Alzheimer’s disease.” The PRIME trial (NCT01677572) is an ongoing Phase 1b study evaluating safety, tolerability, pharmacokinetics, and pharmacodynamics (i.e., the interactions between the body and a compound) of aducanumab in 197 participants, aged 50-90, who had clinical manifestations consistent with prodromal (early) or mild Alzheimer’s disease. Patients were randomized to receive 3, 6, or 10 mg/kg fixed or adjusted doses of either aducanumab or placebo. Both patients treated with fixed or adjusted dose
Subscribe or to access all post and page content.