#AAN2018 – PRIME Trial Data Show Long-term Benefits of Aducanumab in Early Alzheimer’s

#AAN2018 – PRIME Trial Data Show Long-term Benefits of Aducanumab in Early Alzheimer’s
Long-term use of BIIB037 (aducanumab) can prevent progression of Alzheimer’s in patients at early stages of the disease, according to results from the PRIME study. Biogen, maker of aducanumab, will present those results at the 2018 Annual Meeting of the American Academy of Neurology (AAN), April 21-27 in Los Angeles, California. The clinical effects of 24 and 36 months treatment with aducanumab will be presented in two studies, “Aducanumab titration dosing regimen: 24-month analysis from PRIME, a randomized, double-blind, placebo-controlled Phase 1b study in patients with prodromal or mild Alzheimer’s disease” and “Aducanumab 36-month data from PRIME: a randomized, double-blind, placebo- controlled Phase 1b study in patients with prodromal or mild Alzheimer’s disease.” The PRIME trial (NCT01677572) is an ongoing Phase 1b study evaluating safety, tolerability, pharmacokinetics, and pharmacodynamics (i.e., the interactions between the body and a compound) of aducanumab in 197 participants, aged 50-90, who had clinical manifestations consistent with prodromal (early) or mild Alzheimer’s disease. Patients were randomized to receive 3, 6, or 10 mg/kg fixed or adjusted doses of either aducanumab or placebo. Both patients treated with fixed or adjusted doses of aducanumab had a significant reduction in the levels of amyloid plaques in the brain – the hallmark of Alzheimer’s disease. This reduction also was observed in patients who initially were in the placebo group and later switched to aducanumab. Importantly, patients treated with the highest dose for up to 36 months achieved amyloid plaque reductions to levels below the point that allows their detection in scans. Positive data concerning patients’ cognitive and physical function,
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