Ultrasound Wave Therapy Improves Cognition in Mouse Models of Alzheimer’s, Vascular Dementia

Ultrasound Wave Therapy Improves Cognition in Mouse Models of Alzheimer’s, Vascular Dementia
Low-intensity pulsed ultrasound (LIPUS) therapy applied to the whole brain can be an effective, non-invasive strategy to reduce cognitive impairment associated with vascular dementia and Alzheimer's disease, according to results from a mouse study. The study, “Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia — Crucial roles of endothelial nitric oxide synthase,” was published in the journal Brain Stimulation. Some studies have suggested that the therapeutic effects of LIPUS work by stimulating brain cells to release signaling molecules, such as brain-derived neurotrophic factor and nerve growth factor, which could support nerve cell regeneration and provide a neuroprotective effect. Based on these findings, researchers have focused on understanding the benefits of LIPUS when delivered directly to the hippocampus, an area of the brain associated with memory that is affected in dementia. But the hippocampus is not the only region affected in vascular dementia and Alzheimer's disease, two major forms of dementia. These conditions are in fact characterized by widespread lesions and protein aggregate deposition. Accordingly, a team at Tohoku University in Japan evaluated the effectiveness and feasibility of applying LIPUS to the whole brain in mouse models of these diseases. To study this, the researchers
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    Perhaps it is relevant to remember that almost of the failures in Alzheimer’s drug development did wonderfully in the transgenic mouse model. Indeed, if that model was accurate, we should have by now an excess of drugs to prevent and/or treat this disease, that we would not know what to do with them. I believe that some articles should be a little more cautious about this mayor breakthroughs that help mice to fight Alzheimer’s (apparently plain mice do not get this disease), but so far do nothing for humans. One reason is to avoid raising false hopes in those affected by this disease or their love ones. Yet, this message should also be directed to Academic institutions Public Relations departments, that issue press releases about some of their publications, that makes the invention of chicken soup eons ago to look almost inconsequential.

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