Ultrasound Wave Therapy Improves Cognition in Mouse Models of Alzheimer’s, Vascular Dementia

Ultrasound Wave Therapy Improves Cognition in Mouse Models of Alzheimer’s, Vascular Dementia
Low-intensity pulsed ultrasound (LIPUS) therapy applied to the whole brain can be an effective, non-invasive strategy to reduce cognitive impairment associated with vascular dementia and Alzheimer's disease, according to results from a mouse study. The study, “Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia — Crucial roles of endothelial nitric oxide synthase,” was published in the journal Brain Stimulation. Some studies have suggested that the therapeutic effects of LIPUS work by stimulating brain cells to release signaling molecules, such as brain-derived neurotrophic factor and nerve growth factor, which could support nerve cell regeneration and provide a neuroprotective effect. Based on these findings, researchers have focused on understanding the benefits of LIPUS when delivered directly to the hippocampus, an area of the brain associated with memory that is affected in dementia. But the hippocampus is not the only region affected in vascular dementia and Alzheimer's disease, two major forms of dementia. These conditions are in fact characterized by widespread lesions and protein aggregate deposition. Accordingly, a team at Tohoku University in Japan evaluated the effectiveness and feasibility of applying LIPUS to the whole brain in mouse models of these diseases. To study this, the researchers
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