Biohaven Enrolls 1st Patient in Phase 2/3 Trial of Trigriluzole for Mild to Moderate Alzheimer’s

Biohaven Enrolls 1st Patient in Phase 2/3 Trial of Trigriluzole for Mild to Moderate Alzheimer’s
Biohaven Pharmaceuticals has enrolled the first patient in its Phase 2/3 clinical trial investigating the potential of trigriluzole as a treatment for patients with mild to moderate Alzheimer's disease. The study, which is currently recruiting, is being conducted in collaboration with the Alzheimer's Disease Cooperative Study (ADCS) at four clinical sites in the U.S. Trigriluzole, also known as BHV-4157, is a new compound precursor of riluzole — an approved medication for amyotrophic lateral sclerosis (ALS) — designed to regulate glutamate activity, one of the most abundant and important signaling molecules in the brain. It has a wide range of pharmacological actions targeting several mechanisms impaired in Alzheimer’s patients. Preclinical studies in animal models and post-mortem human tissue suggest trigriluzole may protect from Alzheimer's-related pathology and cognitive dysfunction by protecting brain cells and improving their response to glutamate. "Biohaven is committed to efficiently developing novel therapies for severe neurological diseases so this is an important clinical milestone for the company,” Irfan Qureshi, MD, executive director of neurology at Biohaven, said in a
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