Age, Gender, and APOE4 Variant May Help Identify Those at High Risk for Dementia, Study Suggests

Age, Gender, and APOE4 Variant May Help Identify Those at High Risk for Dementia, Study Suggests
The absolute 10-year risk of dementia varies according to age, gender, and common variation in the APOE gene, according to a large-scale Danish study. This discovery may help identify high-risk individuals who may benefit from early targeted intervention to prevent dementia's development and progression. The study, “Absolute 10-year risk of dementia by age, sex and APOE genotype: a population-based cohort study,” was published in the Canadian Medical Association Journal. "Recently, it was estimated that one-third of dementia most likely can be prevented. According to the Lancet Commission, early intervention for hypertension, smoking, diabetes, obesity, depression, and hearing loss may slow or prevent disease development,” Ruth Frikke-Schmidt, from the Rigshospitalet, Copenhagen University Hospital, and senior author of the study, said in a press release. “If those individuals at highest risk can be identified, a targeted prevention with risk-factor reduction can be initiated early before disease has developed, thus delaying onset of dementia or preventing it," she said. The team reviewed the clinical records of 104,537 individuals who had participated in the Copenhagen General Population Study (from 2003 to 2014) and the Copenhagen City Heart Study (from 1991 to 1994 and 2001 to 2003). Among these individuals, 2,160 developed dementia and 7,520 cerebrovascular disease. It is believed that
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