Alternations Seen in RNA Splicing and Protein Creation in Alzheimer’s Disease

Alternations Seen in RNA Splicing and Protein Creation in Alzheimer’s Disease
Using a technique called genome-wide mapping, researchers were able to identify specific variations in RNA splicing from brain tissue taken from 450 people who were part of clinical studies into aging. This work — which identified hundreds of altered splicing events, which affect protein production — in Alzheimer's, and may offer new ways of diagnosing and treating this disease. The study, “Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility,” was published in the journal Nature Genetics. All genetic information contained within genes (DNA) is ultimately translated into proteins. Howeve
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