Beta-amyloid’s Key Role in Alzheimer’s Toxic Clumps and Need for Personalized Medicine Focus of Talk

Beta-amyloid’s Key Role in Alzheimer’s Toxic Clumps and Need for Personalized Medicine Focus of Talk
Increasing evidence places beta-amyloid aggregates at the center of the toxic protein clumps and neuroinflammation that drive Alzheimer’s, two experts in this disease said, and a personalized, combination treatment likely will be the best way of helping patients. These insights were shared at a recent Key Opinion Leader luncheon meeting, hosted by AC Immune in New

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One comment

  1. DANTE MARCIANI says:

    Twenty years ago it was published in Proc. Nat. Acad. Sci. USA. that amyloid-beta oligomers, i.e. soluble aggregates were the cytotoxic agents responsible for Alzheimer’s damage. Shortly after, it was shown that some natural immunoglobulins were protective against AD effect in transgenic animal models. Biogen has two monoclonal antibodies that protect against cyotoxic amyloid-beta. The amyloid-beta vaccines failed, because as designed they were supposed to fail. Perhaps it is long overdue to accept that the whole amyloid beta situation has been a tragicomedy of errors, rather than announcing “new discoveries” that are actually quite old rediscoveries.

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