Phase 2 Trial of Tau Antibody RO7105705 Recruiting Patients with Moderate Alzheimer’s

Phase 2 Trial of Tau Antibody RO7105705 Recruiting Patients with Moderate Alzheimer’s
A Phase 2 trial is enrolling patients with moderate Alzheimer’s to test an investigational antibody known as RO7105705 that targets the Tau protein. The Genentech-sponsored multicenter, randomized study (NCT03828747) intends to assess the efficacy, safety, and pharmacological profile of RO7105705. The company plans to recruit 260 patients in the U.S. More information on study locations and contacts can be found here. After a screening period, patients will receive RO7105705
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    An problem with Alzheimer’s disease is that all the successful studies in transgenic mouse models have delivered only clinical failures. Apparently, if a product does not work in the mouse model would not work at all in humans, but, if it is effective in that animal model, there are no assurances that it will work in humans.
    A potential problem with the monoclonal antibody studies, is that based on the artificial animal model the antibody is always focused on a single lesion; yet, in humans there are indications that amyloid-beta and tau, have a gamma of structural alterations. Hence, blocking one would not affect the others; therefore, it is possible to postulate that a more effective approach would be to use batteries of antibodies against different alterations, i.e. mimic the natural polyclonal antibodies. Another advantage of using various antibodies is the cooperative effects among different antibodies, which would improve their effects on the apparently heterogeneous population of aberrant protein species. In fact, trying to apply directly concepts derived from hormones and their receptors to Alzheimer’s disease, is apparently a good recipe for failure

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