Extract from Native California Plant Shows Neuroprotective Ability Against Alzheimer’s, Study Reports

Extract from Native California Plant Shows Neuroprotective Ability Against Alzheimer’s, Study Reports
Sterubin, an active chemical compound extracted from a native California plant, was found to hold neuroprotective and anti-inflammatory potential for Alzheimer's disease, a study shows. The study, “Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa,” was published in the journal Redox Biology. Many therapeutic agents used to treat several diseases are based on chemical compounds found in nature, which have been used for centuries in traditional medicine. With this in mind, researchers from the Salk Institute for Biological Studies in California decided to explore the potential of 400 different plant extracts to target known mechanisms involved in Alzheimer's disease. To evaluate the potential of the extracts, the team used a cell-based assay that enabled the identification of those that could specifically prevent a type of nerve cell death called oxytosis. Oxytosis is a form of regulated cell death that is triggered by reduced levels of the antioxidant molecule glutathione, impaired transport of the nerve cell activator glutamate, and increased production of damaging oxygen reactive elements. This process has been described as rele
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