Trial Begins Testing Blood-derived GRF6019 Therapy for Severe Alzheimer’s Disease

Trial Begins Testing Blood-derived GRF6019 Therapy for Severe Alzheimer’s Disease
The first patient has been dosed in Alkahest's Phase 2 clinical trial testing its investigational therapy, GRF6019, in individuals with severe Alzheimer's disease. The study (NCT03765762) was designed to assess the safety and tolerability of the experimental treatment, as well as its impact on patients' mental state and capacity to perform daily activities. Researchers will also collect information on overall symptom changes as reported by patients and their caregivers. The trial is currently recruiting at sites in Arizona and Florida in the United States. Up to 20 participants with severe Alzheimer's disease, as defined by Mini-Mental State Examination scores between 0 and 10, will be randomized to receive daily intravenous infusions of GRF6019 or a placebo for five consecutive days and followed for up to nine weeks. Alkahest, and its collaborator Grifols, expect to announce results from this Phase 2 trial during the second half of 2020. For more information about the study, such as clinical site locations and contacts, click here. “Patients at more advanced stages of Alzheimer's disease are rarely included in clinical trials, and this novel approach could provide a novel treatment option for these individuals," Karoly Nikolich, PhD, chairman and CEO of Alkahest, said in a
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