Two prescription treatments for heart disease and angina — cilostazol and isosorbide mononitrate — show a potential to prevent or reduce vascular dementia, a study reports. They also can be safely used in people with a history of stroke, which was the focus of this research. Because vascular dementia and evidence of disease affecting small blood vessels in the brain are found in Alzheimer's patients, these results may also point to a way of slowing or preventing the cognitive decline associated with this disease's development. Recent research also identifies stroke as a major factor for both vascular dementia and Alzheimer’s disease. The study, “Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial,” was published in the journal EClinicalMedicine. Researchers in the U.K. reviewed literature and identified two current medications with the potential to improve blood vessel function in the brain after a stroke, especially what's known as a lacunar ischaemic stroke that's brought on by obstructed blood flow, and subsequently oxygen supply, in the brain.