Vaccine Decreases Tau Tangles, Improves Memory and Motor Function in Mouse Model of Alzheimer’s, Study Says

Vaccine Decreases Tau Tangles, Improves Memory and Motor Function in Mouse Model of Alzheimer’s, Study Says
An experimental vaccine targeting the toxic form of tau protein reduced cellular tangles in the brain — a hallmark of Alzheimer’s — and eased behavioral and motor defects in a mouse model of the disease, a study showed. By generating high levels of anti-tau antibodies, this vaccine may slow disease course and could advance to clinical trials, the scientists said. The study, “A MultiTEP platform-based epitope vaccine targeting the phosphatase activating domain (PAD) of tau: therapeutic efficacy in PS19 mice,” was published in the journal Nature. Alzheimer’s is characterized by the formation of amyloid plaques and tau tangles in the brain, which disrupt communication between nerve cells and cause their death.  Research efforts to develop treatments have mainly focused on amyloid plaques, with clinical trials showing only limited success. However, tau tangles, or neurofibrillary tangles, are more strongly correlated with disease progression and have become a promising therapeutic target. As supported by studies in anima
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