Ionis Licenses IONIS-MAPTRx Antisense Therapy for Alzheimer’s to Biogen

Ionis Licenses IONIS-MAPTRx Antisense Therapy for Alzheimer’s to Biogen
Ionis Pharmaceuticals has licensed IONIS-MAPTRx (BIIB080), its investigational antisense therapy for the treatment of Alzheimer’s disease, to Biogen. IONIS-MAPTRx is an antisense therapy — an approach to fighting diseases using short DNA-like molecules called antisense oligonucleotides — that has been designed to reduce the production of the microtubule-associated protein tau (MAPT), or tau. Tau is thought to cause, or at least contribute to the development of several neurodegenerative diseases, including Alzheimer’s and some forms of frontotemporal degeneration (FTD). The therapy works by selectively targeting and preventing the messenger RNA (mRNA) containing information to produce tau from being translated into a functional protein. "The licensing of IONIS-MAPTRx, currently in a Phase 1 clinical study in mild AD [Alzheimer’s disease] patients, is an important milestone for the program. It brings us another step closer to potentially delivering a therapy to patients who have few or no effective treatment options," Brett P. Monia, PhD, Ionis' chief operating officer, said in a press release. Ionis will receive an upfront
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