Advanced Imaging Captures Protein Clumps in Neurons at Early Alzheimer Stages

Advanced Imaging Captures Protein Clumps in Neurons at Early Alzheimer Stages
Scientists used a new imaging technique to assess the structure of amyloid-beta aggregates — known culprits in Alzheimer's development — that are present inside nerve cells at early stages of the disease, a study reports. These findings, from a mouse model, may be important to understanding the different stages of Alzheimer's progression. The study, “Super‐Resolution Infrared Imaging of Polymorphic Amyloid Aggregates Directly in Neurons,” was published in the journal Advanced Science. During the development of Alzheimer's, a protein called amyloid-beta clumps and forms aggregates inside nerve cells (neurons). Over time, these aggregates become plaques that accumulate between nerve cells and disrupt their communication. These amyloid-beta plaques are toxic to nerve cells, and as the disease progresses, they cause nerve cells to
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