The first patient enrolled in the ADvance II Study has been implanted with a deep brain stimulation (DBS) device to start treatment for mild Alzheimer’s disease. The study will evaluate the safety and effectiveness of stimulating the fornix (DBS-f) — a major inflow and output pathway…
An online test, called MemTrax, may help screen and predict the progression of cognitive impairment in Alzheimer’s and other disorders, according to a new study using artificial intelligence. The research, “Episodic-Memory Performance in Machine Learning Modeling for Predicting Cognitive Health Status Classification,” was published in…
Two Phase 3 clinical trials testing the investigational therapy aducanumab in patients with early Alzheimer’s disease have been discontinued. Biogen and Eisai came to this decision after an analysis from an independent data monitoring committee indicated that the global ENGAGE (NCT02477800) and EMERGE (NCT02484547)…
Combining two dietary compounds found in green tea and carrots reversed cognitive deficits, lowered the accumulation of toxic amyloid beta, and reduced brain inflammation and oxidative damage in a mouse model of Alzheimer’s disease, a study reports. The study, “Combined treatment with the phenolics (−)-epigallocatechin-3-gallate and ferulic…
A Phase 2 trial is enrolling patients with moderate Alzheimer’s to test an investigational antibody known as RO7105705 that targets the Tau protein. The Genentech-sponsored multicenter, randomized study (NCT03828747) intends to assess the efficacy, safety, and pharmacological profile of RO7105705. The company plans to recruit 260…
Herpes simplex virus type 1 (HSV1) may be linked to Alzheimer’s development, and antiviral therapies lower the risk of senile dementia in patients with severe herpes infections, according to a review study. The research, “Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer’s Disease,”…
Researchers have discovered a new mechanism targeted by the leukemia therapy Sprycel that may contribute to Alzheimer’s and traumatic brain injury. The team, which effectively targeted this mechanism in a mouse model of Alzheimer’s, now hopes to replicate the test in humans. The study, “Oxidation of…
Small proteins found in sea anemones can protect nerve cells from the toxic effects of beta-amyloid, a hallmark of Alzheimer’s, and may one day point to a way of treating this disease, a study reports. The research, “A New Iq-Peptide of the Kunitz Type from the Heteractis magnifica Sea…
Intensive efforts to lower blood pressure — dropping systolic blood pressure, particularly, to lower-than-recommended levels — can reduce a person’s risk of the mild cognitive impairment that may precede Alzheimer’s and of dementia, results of clinical trial show. “This is the first randomized clinical trial to demonstrate a reduction in…
The hallmark Alzheimer’s disease protein tau requires a specific “sulfate code” to enter cells and alter normal proteins, according to a new study. Also, the identification of enzymes involved in the cellular uptake of corrupted proteins could lead to new therapies for neurodegenerative diseases, researchers say. The research, “…
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