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Reduced levels of the blood coagulation factor XII improves brain inflammation and cognitive deficits in Alzheimer’s disease, new research shows. The study, “Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer’s disease mice,” appeared in the journal Blood. Vascular (blood vessel) dysfunction and inflammation…

Canada’s 3D Signatures has developed a simple cheek swab to identify patients with Alzheimer’s disease (AD), and even distinguish among those with mild, moderate or severe stages of the illness, according to results from a clinical trial. The analyses, based on the company’s TeloView software platform, will appear in the Journal of Alzheimer’s Disease, though a 3D press…

With the help of an extremely powerful infrared spectroscopy method, researchers have found evidence challenging the widely held theory that Alzheimer’s disease can be prevented by clearing amyloid-beta from the brain. The research team at Lund University in Sweden discovered that amyloid-beta naturally exists as a four-unit complex and…

Drinking tea may lower the risk of developing Alzheimer’s disease and other neurocognitive ailments, concludes a study that followed elderly adults in Singapore. Since objectively measurable markers of tea consumption are now available, researchers at the National University of Singapore urge more efforts to examine the individual compounds in tea responsible for this…

Abnormal levels of calcium in the mitochondria, the cell’s powerhouse, may lead to neuronal death in Alzheimer’s disease and dementia, according to researchers at Temple University’s Center for Translational Medicine. Scientists presented their study, “Imbalance of calcium in a cell’s energy factory may drive Alzheimer’s disease,” at the 61st Meeting of the Biophysical Society,…

Caffeine, along with 23 other compounds, increases levels of a neuroprotective enzyme called NMNAT2 (nicotinamide mononucleotide adenylyl transferase 2), with potential implications for the treatment of dementia, new research shows. The study, “Screening with an NMNAT2-MSD platform identifies small molecules that modulate NMNAT2 levels in cortical neurons,” appeared in…

The University of Wisconsin-Madison’s Alzheimer’s Disease Research Center and Cerveau Technologies are partnering in research on the stages of Alzheimer’s and other neurodegenerative diseases. Wisconsin established the center in 2009 to focus on preclinical Alzheimer’s. Cerveau is a partnership between Enigma Biomedical Group and Sinotau Pharmaceutical Group. It was created to…

The diabetes drug Symlin (pramlintide) may help scientists develop novel and faster diagnostic tests for Alzheimer’s disease (AD), a study indicates. The research, “An amylin analog used as a challenge test for Alzheimer’s disease,” was published in the journal Alzheimer’s & Dementia: Translational Research & Clinical Interventions. At…

Israel’s Neurim Pharmaceuticals is now recruiting up to 500 U.S. patients with mild Alzheimer’s disease for a Phase 2 trial to study the safety and efficacy of its experimental drug, piromelatine. Alzheimer’s is caused by the accumulation of faulty proteins that lead to the formation of beta-amyloid plaques, which greatly…

Roche and MorphoSys will partner on experimental Phase 3 clinical trials to study the effectiveness and safety of gantenerumab in patients with early to mild Alzheimer’s disease. Roche, a Swiss global healthcare company, will start preparing two studies soon, according to MorphoSys, a German biotechnology company that developed gantenerumab. The trials will…