Elenbecestat (formerly E2609) was an oral therapy that Eisai and Biogen were developing to delay the start of early-stage Alzheimer’s disease and perhaps stop its progression. In September of 2019, Eisai and Biogen decided to discontinue investigation into the drug after their Data Safety Monitoring Board found an unfavorable risk-to-benefit ratio for patients.

How elenbecestat works

Alzheimer’s disease is characterized by a build-up of beta-amyloid plaques in the brain, which damages nerve cells. The plaques are formed when the beta-amyloid cleaving enzyme, or BACE1, cuts the “parent” beta-amyloid protein into pieces. This parent protein is known as the amyloid precursor protein or APP.

Elenbecestat was a BACE1 inhibitor. It was designed to reduce beta-amyloid plaque formation by preventing the BACE1 enzyme from cutting up APP.

Elenbecestat in clinical trials

Studies in animals showed that elenbecestat can lower beta-amyloid levels in the brain, the cerebrospinal fluid that envelops the brain and spinal cord, and the blood.

Eisai and Biogen have conducted nine Phase 1 clinical trials of elenbecestat, eight of which were completed by March 2015.

The first two trials showed that participants could tolerate oral doses of up to 200 mg of elenbecestat, with dizziness and headaches being the most common side effects.

A Phase 2 trial (NCT02322021) that began in November 2014 investigated whether elenbecestat was safe and could slow the progression of Alzheimer’s disease in 70 patients with mild cognitive impairment, or mild to moderate dementia. During the trial, patients receive either a placebo or 5, 15, or 50 mg of elenbecestat in single daily doses over 18 months. Eisai reported that no serious adverse reactions were noted in any of the treatment arms. The 50 mg elenbecestat group also showed significantly reduced levels of beta-amyloid compared to the placebo group.

Eisai and Biogen started two Phase 3 trials in 2016 called MISSION AD1 (NCT02956486) and MISSION AD2 (NCT03036280). The main goal of the studies was to further investigate the effectiveness of the 50 mg dose of elenbecestat. 

The plan was for 1,330 patients to receive 50 mg of elenbecestat daily for two years. There were multiple measures of effectiveness: whether the treatment could reduce the severity of dementia symptoms; if it could lower beta-amyloid levels in the brain; whether it could prevent deterioration of the hippocampus, a brain region that Alzheimer’s disease has a major effect on; and whether it could reduce levels of Alzheimer’s disease biomarkers in the cerebrospinal fluid.

Eisai also announced that elenbecestat was selected by the Alzheimer’s Clinical Trial Consortium (ACTC) to be included in a new clinical trial targeting primary prevention of Alzheimer’s disease, called A3, which would have begun in 2020.

Mission AD1 and AD2 were both terminated in September of 2019 following recommendations from the Data Safety Monitoring Board. Interim data analysis showed an unfavorable risk-to-benefit ratio for patients. After these results, Eisai and Biogen have decided to discontinue research into elenbecestat. Detailed data analysis of the trials will be presented at medical conferences in the future.

Other details

Eisai announced in 2016 that the U.S. Food and Drug Administration had granted fast-track status to elenbecestat. Fast track status is aimed at accelerating the development and regulatory review of treatments for serious conditions and that fill an unmet need.

 

Last updated: Sept. 13, 2019

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