Two Additional Amino Acids in Toxic Protein Sequence Form Resilient Alzheimer’s Plaques, Study Shows

Researchers at Virginia Commonwealth University (VCU) have found that the presence of two additional amino acids in the amyloid beta (Aβ) protein sequence forms the basis of amyloid plaque formation and Alzheimer’s disease development. Their study, “Few Ramachandran Angle Changes Provide Interaction Strength Increase in Aβ42 versus Aβ40 Amyloid Fibrils,” appeared…

Amyloid-Beta42 Structure Unravels its Aggregation and Toxicity in Alzheimer’s Disease

In a new study entitled “Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer’s disease,” researchers established the molecular structure of a key form of amyloid-β (Aβ) protein, Aβ42. This finding allows researchers to understand how Aβ42 accumulates in plaque aggregates in the brain of…