The first patient has been dosed in the resumed Phase 2a clinical trial of montelukast for mild to moderate Alzheimer’s disease. IntelGenx, the company running the study known as BUENA (NCT03402503), suspended the trial in late 2020 due to increased concern regarding the COVID-19 pandemic. “Resumption of…

The Adira Foundation is inviting people with neurodegenerative diseases and their caregivers to join a grant proposal review committee. A nonprofit foundation, its mission is to unite people affected by some of most common neurodegenerative diseases — namely, Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and multiple sclerosis —…

The hallmark Alzheimer’s disease protein tau requires a specific “sulfate code” to enter cells and alter normal proteins, according to a new study. Also, the identification of enzymes involved in the cellular uptake of corrupted proteins could lead to new therapies for neurodegenerative diseases, researchers say. The research, “…

Scientists are coming closer to understanding how the gene variant apolipoprotein E4 (ApoE4) raises the risk of Alzheimer’s disease. Blocking ApoE4 — one of several variants of the ApoE gene — in the brain may prevent cell death and inflammation and lead to a treatment for Alzheimer’s, concludes a study, “ApoE4…

Patients with dementia or other neurodegenerative diseases may die earlier if family members who act as caregivers have poor mental health, according to a study published recently in the Proceedings of the National Academy of Sciences (PNAS). While depression and anxiety among caregivers has been linked to a poorer…

Researchers have discovered a common link between abnormal proteins that cause damage to brain cells in Alzheimer’s (AD), Parkinson’s (PD) and Huntington’s (HD) disease patients. The discovery could help scientists understand the mechanism by which these neurodegenerative diseases spread, and possibly lead to a therapy…

An air pollutant found in industrial areas, magnetite, could be contributing to the development of neurological conditions such as Alzheimer’s disease (AD), according to new study out of the United Kingdom and Mexico. The study, “Magnetite pollution nanoparticles in the human brain,” was recently published in the journal Proceedings of the…

Toronto researchers have examined the driving ability in people with cognitive impairments, including those with Alzheimer’s disease. The recent report, “A Systematic Review and Meta-Analysis of On-Road Simulator and Cognitive Driving Assessment in Alzheimer’s Disease and Mild Cognitive Impairment,” appeared in the Journal of…

A new study led by biomedical scientists at Indiana University has revealed evidence that the NMNAT2 enzyme may be protective against the debilitating effects of certain degenerative disorders, including Alzheimer’s Disease. The study, “NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies,” was published in the journal…

Chronic activation of the innate immune system is the main cause of a range of symptoms common to different neurodegenerative diseases, namely dementia, which is often associated with Alzheimer’s disease, researchers at the University of Adelaide reported. Their study, titled “The Enemy within: Innate Surveillance-Mediated Cell Death, the Common Mechanism…