Genetic Alterations Contribute to Cognitive Decline in Alzheimer’s Patients

Genetic Alterations Contribute to Cognitive Decline in Alzheimer’s Patients
cognitive declineFor some Chinese Alzheimer's disease patients, genes can have an impact on cognitive decline. A recent study from Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, entitled "APOE and APOC1 Gene Polymorphisms Are Associated with Cognitive Impairment Progression in Chinese Patients with Late-Onset Alzheimer's Disease," described the impact of specific genetic alterations on cognitive impairment progression for a subset of Alzheimer's patients. In total, 78 Chinese Han patients with late-onset Alzheimer's disease from Guangxi Zhuang Autonomous Region in China were followed for 30 months. At the beginning of the study, patients were screened for genetic alterations in the genes encoding apolipoprotein E (APOE), apolipoprotein C1 (APOC1), and low density lipoprotein receptor-related protein (LRP). Throughout the longitudinal study, patients were assessed for cognitive function using the Mini-Mental State Examination (MMSE) and the Clinical Dementia Rating (CDR) Scale
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