Pathway in Brain Contributes to Alzheimer’s Disease

Pathway in Brain Contributes to Alzheimer’s Disease
shutterstock_72441307A new study entitled “Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer’s Disease," published in the online issue of Neuron, reports the discovery of a key pathway to the progression of Alzheimer’s Disease. Alzheimer’s disease is characterized by synaptic loss and dementia. Previously, genetic variants of a receptor for low-density lipoprotein 6 (LRP6) were linked with Alzheimer’s disease. Now a team of scientists from the Mayo Clinic in Jacksonville, Florida discovered that LRP6 in the neurons mediates a signal, via Wnt, which is crucial for hypnotic function and cognition. A conditional deletion of the Lpr6 gene in mouse forebrain neurons impaired Wnt signaling and exhibited a deficit in synaptic integrity and memory. Additionally, the authors found that this defect exacerbates amyloid beta deposits in the brain (the main protein in amyloid plaques found in Alzheimer’s disease patients). Wnt signaling has crucial functions in cell survival and synaptic activity and imbalance Wnt activity was linked to cancer. Now, the team led by Guojun Bu, Ph.D., a neuroscientist at MayoClinic, Jacksonville, Florida is the first linking suppressed Wnt signaling a
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