Close Link Between Down Syndrome, Alzheimer’s Disease Unlocked By Researchers

Close Link Between Down Syndrome, Alzheimer’s Disease Unlocked By Researchers
A study entitled “SortingNexin 27 Regulates Aβ Production through Modulatingγ-Secretase Activity” published in the online issue of Cell Reports reveals common molecular mechanisms between Down syndrome and Alzheimer’s disease, with clear implications for the development of therapeutics against neuro-disorder diseases. Down syndrome (DS), or trisomy 21 patients — who carry an extra copy of the 21 chromosome — have an increased risk of developing Alzheimer's disease (AD). In fact, nearly 100 percent of DS patients by the age of 40 develop AD-like neuropathology. One of the characteristic AD phenotypes that is also observed in DS patients is the accumulation of neurotoxic beta-amyloid peptides. While the extra chromosome 21 in DS patients may lead to the overproduction of beta-amyloid precursor protein, the molecular mechanism of AD-like neurodegeneration in DS patients is still largely unclear. Huaxi Xu, Ph.D., professor in the Degenerative Diseases Program at Sanford-Bu
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