New Study Uncovers Insights Into Brain Aging, Neurogenererative Diseases, such as Alzheimer’s

New Study Uncovers Insights Into Brain Aging, Neurogenererative Diseases, such as Alzheimer’s
brain agingA study entitled “A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease” recently published in the journal Cell Reports, identifies a subset of chaperones that protect protein-correct folding in aging brains and neurogenererative diseases, such as Alzheimer's. In this study, a team of scientists at Proteostasis Therapeutics, Inc., Northwestern University and Harvard University performed a comprehensive genetic analysis of human brain tissue during healthy individuals' normal aging and in those affected with neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's. They found that a specific subset of the chaperone human network declines with age in the brains of healthy individuals but, in humans affected by neurodegenerative diseases, the decline is actually much more rapid. Chaperones are a class of proteins that form a patrolling system identifying misfiled proteins and help their refolding into the correct shape -- a key event in protein homeostasis and healthy cells. The researchers found that one-third of the human chaperones decline with age. From these, 28 human genes were specifically associated with aging brains and diseases such as Huntington's. As such, the authors pr
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *