Alzheimer’s Development Captured Using PET, MRI Imaging

Alzheimer’s Development Captured Using PET, MRI Imaging
MRI ScanIn a recent study entitled “Longitudinal PET-MRI reveals β-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion” the authors developed a new imaging protocol that allows detection and examination of Alzheimer's Disease typical beta-amyloid plaques. The study was published in the online issue of NatureMedicine. Alzheimer's (AD) is a neurodegenerative disease characterized by extracellular beta-amyloid (β-amyloid) deposits, forming the amyloid plaques that are considered a fundamental cause for the disease. Thus, it is essential to detect the onset of β-amyloid deposition and its associated effects, such as regional cerebral blood flow (rCBF). In this study, the team of neuroscientists led by Professor Bernd Pichler of the Werner Siemens Imaging Center at Tübingen University's Department of Preclinical Imaging and Radiopharmacy, developed a new imaging protocol that allowed the researchers to follow the formation of amyloid plaques in the brain of two transgenic mouse models for AD. The new protocol combines two non-invasive techniques — positron emission tomography (PET) and magnetic resonance imaging (MRI). During the lifetime of the mice, the authors examined their brains with two differ
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