Alzheimer’s Might Be Prevented By Protein That Wakes the Brain Up From Sleep

Alzheimer’s Might Be Prevented By Protein That Wakes the Brain Up From Sleep
orexinA brief study entitled “Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease” identified orexin, a protein that triggers the brain to wake after sleeping, as a potential new factor in Alzheimer's disease. The study was published in November issue of The Journal of Experimental Medicine. Previous studies showed humans with preclinical evidenced Alzheimer's disease exhibit sleep disturbances, both in duration and quality. While Alzheimer's disease is characterized by the accumulation of amyloid beta protein plaques, and that this accumulation progresses with the disease and leads to the symptoms of dementia and memory loss, how sleep deprivation and duration affects amyloid beta protein plaques' accumulation is not well understood. In this study, a team of researchers at the Washington University School of Medicine in St. Louis aimed to understand this link, and they bred mice genetically modified to accumulate amyloid beta plaques with mice who lack the gene for orexin. They observed that the offspring of this mating exhibited an increased sleep duration with significantly reduced accumulation of amyloid b
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *