Researchers Identify Genes and Pathways Associated with Neurodegeneration

Researchers Identify Genes and Pathways Associated with Neurodegeneration
brainA recent study published in the journal Experimental Biology and Medicine revealed genes and signaling pathways associated with neuronal death and neurodegeneration. The study is entitled “Featured Article: Transcriptome profiling of expression changes during neuronal death by RNA-Seq.Neuronal death is a natural process that is part of brain development. However, if this process of elimination of neurons is not properly regulated, it becomes a major cause of neurodegenerative diseases like Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). The molecular mechanisms underlying neuronal death, either as a natural process or linked to degenerative brain disorders, are not clear. Because of this, it is important to determine the genes that can potentially promote or block neuron elimination. The team, led by researchers at Southern Methodist University in Dallas, conducted a comprehensive analysis of transcriptome expression alterations (i.e., at the level of RNA, the messenger of genetic in
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