Dieting Produces Metabolite that Prevents Inflammation in Alzheimer’s Disease

Dieting Produces Metabolite that Prevents Inflammation in Alzheimer’s Disease
shutterstock_210296845In a new study entitled “The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease,” researchers report to have found a natural body producing metabolite – β-hydroxybutyrate (BHB) — capable of blocking NLRP3 inflammasome activation, a multi protein complex that promotes secretion of pro-inflammatory cytokines and is a key mediator in inflammatory diseases and conditions that are known to be driven by states of inflammation, such as Alzheimer's Disease. The study was published in the journal Nature Medicine. Ketone bodies, including the β-hydroxybutyrate (BHB) and acetoacetate (AcAc) are normally produced by the liver of mammals during fasting conditions and serve as alternative energy sources, instead of glucose, for several key organs — brain, heart and skeletal muscles. During prolonged fasting, the concentration of ketone bodies increase significantly, and this switch from glucose to ketone bodies (fasting period) is associated with changes in immune cells function. However, whether ketone bodies impact the innate immune response is currently unknown. In this new study, a research t
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