Biogen Idec Clinical Trial Reveals a Promising Therapeutic Drug for Alzheimer’s Disease

Biogen Idec Clinical Trial Reveals a Promising Therapeutic Drug for Alzheimer’s Disease
brainBiogen Idec recently announced the results from a pre-specified interim analysis of PRIME, an ongoing Phase 1b randomized, double-blind, placebo-controlled trial to evaluate the safety, tolerability, pharmacodynamics and pharmacokinetics of aducanumab (BIIB037) in patients with early or mild Alzheimer’s disease. The results were presented at the 12th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders in Nice, France. Alzheimer’s disease is a neurodegenerative disorder where individuals initially experience memory loss and confusion that gradually leads to behavior and personality changes, a decline in cognitive abilities, and ultimately to severe loss of mental function. The disorder is characterized by the accumulation of amyloid proteins forming aggregates (amyloid plaques) in the brain and the loss of the connection between neurons responsible for memory and learning. The amyloid plaques are thought to play a crucial role in the development of the disease symptoms. There is currently no cure for Alzheimer's disease. Aducanumab is a therapeutic experimental drug against Alzheimer’s disease that corresponds to a human recombinant monoclonal antibody, which targets the aggregates of beta amyloid proteins, including soluble oligomers and insoluble fibrils in the amyloid plaques. Researchers found that aducanumab tre
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