New Insight into the Association Between Cognitive Reserve and Alzheimer’s Disease Severity

New Insight into the Association Between Cognitive Reserve and Alzheimer’s Disease Severity
Researchers at the Hospital de Magalhães Lemos and the Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto in Portugal recently revealed that a patient’s ability to cope with the neurodegenerative process in disorders like Alzheimer’s disease can influence disease severity. The study is entitled “Cognitive reserve and the severity of Alzheimer's disease” and was published in the journal Arquivos de Neuro-Psiquiatria. Alzheimer’s disease is an age-related, neurodegenerative disorder characterized by cognitive and behavioral problems. It is the most common form of dementia in the elderly with patients initially experiencing memory loss and confusion that gradually leads to behavior and personality changes, a decline in cognitive abilities and ultimately to severe loss of mental function. Alzheimer’s disease is characterized by the brain formation of amyloid plaques (composed of beta-amyloid proteins), and the loss of the connection between neurons that are responsible for memory and learning leading to their eventual death. Cognitive reserve (CR) refers to the ability of the adult brain to cope with the consequences of the neurodegenerative process, while minimizing the clinical pathological manifestations of dementia. CR is thought to be the result of innate intelligence or life experiences (such as education, occupation and leisure a
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