Researchers Find Novel Mechanism for DNA Repair

Researchers Find Novel Mechanism for DNA Repair
In a new study entitled "Novel DNA repair mechanism brings new horizons: Researchers discover new mechanism of DNA repair, which will help to treat and to prevent diseases in the future" researchers discovered a new mechanism on how the DNA molecule repairs itself which may translate into new therapeutics for several diseases, including Alzheimer’s disease. The study was published in the open access online-only journal Science Advances. Within the different types of DNA damage that occurs in cells, single-strand breaks (SSBs) are the most common. However, cells developed a detection and repair system collectively known as the DNA damage response, for which the molecular mechanisms are not completely understood. The DNA molecule has a length of about two meters but it is densely packed inside our microscopic cell nucleus into structures called nucleosomes, as explained by Dr. Vasily M. Studitsky, study lead author and head of the Laboratory of Regulation of Transcription and Replication at the Biological Faculty of the Lomonosov Moscow State University, "In higher organisms DNA is bound with proteins in complexes called the nucleosome. Every ~200 base pairs are organized in nucleosomes, consisting of eight histone proteins, which, like the thread on the bobbin, wound double helix of DNA, which is coiled into two supercoiled loops. Part of the surface of the DNA helix is hidden, because it interacts with histones. Our entire genome is packed this way, except for the areas, from which the information is being currently read." In this study, the research team led by Dr. Vasily M. Studitsky studied how single-stranded DNA breaks are detected in the DNA strand that is left in the nucleosome at the time of transcription. i.e., whenever there is the need to synthesi
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