Apolipoprotein E2 May Act as a Protective Shield in Alzheimer’s

Apolipoprotein E2 May Act as a Protective Shield in Alzheimer’s
In a new study entitled “Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer’s Disease Prevention and Early Intervention” researchers reported a breakthrough discovery when they showed ApoE2 human protein is a protective shield against Alzheimer’s disease, enhancing brain glucose metabolism and amyloid protein homeostasis. The study was published in the Journal of Alzheimer's Disease. Alzheimer’s disease is a devastating condition that progressively destroys memory and thinking skills. Currently affecting more than 5.1 million Americans, estimates point that in the future this number will triplicate. Without any cure in the horizon, despite over 100 human trials already performed, Alzheimer’s research continues in search of an effective treatment, as Liqin Zhao, assistant professor of pharmacology and toxicology at the University of Kansas School of Pharmacy noted, “There is no cure for Alzheimer’s disease. Five available Alzheimer’s disease drugs were all approved by FDA 10 years ago, and they provide only temporary symptomatic relief for an average of six to 12 months.” Now, Dr. Zhao's team has discovered that a protein called ApoE2, one of th
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