Protein May Be Linked to Alzheimer’s Disease and Future Means of Treatment

Protein May Be Linked to Alzheimer’s Disease and Future Means of Treatment
Researchers at the Thomas Jefferson University have found a new protein involved in synaptic pathways with important implications in Alzheimer's disease. The research paper, entitled “Anchoring and synaptic stability of PSD-95 is driven by ephrin-B3,” was published in Nature Neuroscience. Synapses are electrical or chemical signals between nerve cells that allow them to communicate with each other, and are therefore essential to neuronal function. As such, failure and impairment of synaptic function and structure are important factors in Alzheimer’s disease pathogenesis. PSD-95 is part of the membrane-associated guanylate kinase (MAGUK) superfamily of proteins, responsible for regulating synapse development and with implications in deterioration and disease. Despite being key factors in synapse activity, it is still poorly understood how these proteins reach the synaptic location. Through a series of imaging and biochemical techniques and in vivo models, scientists have demonstrated that the protein ephrin-B3 plays a key role in defining the localization and stability of PSD-95, with a direct effect in neuronal activity changes. The study’s results showed that when ephrin-B3 protein dispersed, and consequently its level at the synapses was lower, PSD-95 would also leave the synapse. Dr. Matthew Dalva, associate professor of Neuroscience at the Sidney Kimmel Medical College at Thomas Jefferson University and senior author of the research paper, co
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *