Alzheimer’s GeneMatch Aims to Advance Research into Disease Prevention

Alzheimer’s GeneMatch Aims to Advance Research into Disease Prevention
GeneMatch, a novel program developed by the Banner Alzheimer's Institute (BAI), is now identifying and recruiting people interested in participating in Alzheimer’s disease (AD) research studies who are at risk of developing the disease based on their APOE genetic information. The APOE gene is a genetic factor associated with a higher Alzheimer's risk and a higher risk of early onset AD. The Alzheimer’s Prevention Registry created the GeneMatch program to match a large group of volunteers, 55 to 75 years old, to research studies based on their genetic information and degree of risk. The participation process starts with enrollment and consent at the program’s website. Participants are then provided with a cheek swab to determine their APOE type allele (copies of the gene). The GeneMatch team then matches this information to ongoing studies, and informs the participant of research opportunities. The genetic information is not disclosed to the participant and is kept confidential. “Many families of patients with the disease have felt helpless after hearing about a loved one's Alzheimer's diagnosis,” said Pierre Tariot, MD, director at BAI and co-director of the Alzheimer's Prevention Initiative (API). “GeneMatch gives those family members and any individual willing to take part in the fight against Alzheimer's the opportunity to take action and be part of the movement to end this disease before another generation is lost.” The program, currently enrolling in the United States, has certain other requirements — participants must reside in the U.S and have no cognitive impairment diagnosis, such as AD, dementia, or mild cognitive impairment, in line with API's objective of finding Alzheim
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