NIH Launches Program to Investigate Link Between Alzheimer’s and Vascular Disease

NIH Launches Program to Investigate Link Between Alzheimer’s and Vascular Disease
The National Institute on Aging (NIA) and the National Institute of Neurological Disorders and Stroke (NINDS), both part of the National Institutes of Health (NIH), have launched the Molecular Mechanisms of the Vascular Etiology of Alzheimer’s Disease (M²OVE-AD) Consortium to better understand how the body's vascular system, its network of large and small blood vessels, contributes to Alzheimer’s disease. The program is set for five years and has an allocated budget of $30 million. The consortium is composed by a multidisciplinary team of scientists that, focusing on different approaches, will dissect the molecular mechanisms by which vascular factors impact Alzheimer’s disease onset and progression, and hopefully identify new potential therapeutic targets. “A growing body of research suggests vascular damage often contributes to Alzheimer’s disease. This focused collaborative effort may push our understanding of Alzheimer’s disease over a tipping point and facilitate the development of better treatments for those who are suffering,”Roderick Corriveau, PhD, program director at NINDS, said in a press release. Using brain tissue donated by deceased Alzheimer’s research participants, and blood cells and plasma donated by living participants with various types of vascular risks, researchers will investigate molecular patterns. They will then combine the molecular data with cognition and brain imaging to develop mathematical models for understating how vascular risk factors impa
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