Regulating Body Temperature May Ease Alzheimer’s Disease Symptoms

Regulating Body Temperature May Ease Alzheimer’s Disease Symptoms
Researchers at Université Laval in Canada demonstrated that aging mice in a model of Alzheimer’s disease (AD) were less able to regulate their body temperatures, and when exposed to a cold environment showed increased AD manifestations. These results suggest correction of thermoregulation might be a therapeutic avenue for Alzheimer’s. The study, “Impaired thermoregulation and beneficial effects of thermoneutrality in the 3xTg-AD model of Alzheimer’s disease (AD),” was published in Neurobiology of Aging. The accentuated incidence of AD in older people is accompanied by a reduction in energy metabolism and core body temperature. Researchers investigated if changes in body temperature regulation would amplify the debilitating manifestations of the disease, and if such effects would manifest in a vicious circle, as areas of the brain involved in thermoregulation are affected in Alzheimer’s. To test the hypothesis, the team used a mouse model of AD, the 3xTg-AD,  that presents the hallmarks of the disease, including beta-amyloid production, formation of plaque, synapse loss, and memory loss starting at 6 months. Compared to normal mice, the AD mice were less effective in maintaining their body temperature, spontaneously developing a lower basal temperature as they grew older. The difference between transgenic and normal control mice reached almost 1° Celsius (about 1.8° Fahrenheit) at 12 months of age. Moreover, AD mice were more vulnerable to low temperatures, and clinical manifestations of AD more noticeable when they were exposed to a colder environment. After a 24-hour exposur
Subscribe or to access all post and page content.