Immune Molecule, IL-33, Seen to Reverse Alzheimer’s Pathology in Mouse Model

Immune Molecule, IL-33, Seen to Reverse Alzheimer’s Pathology in Mouse Model
An immune molecule called IL-33 can reverse Alzheimer’s disease symptoms and cognitive decline in mice, researchers show in a study published in the journal Proceedings of the National Academy of Sciences (PNAS). The findings lend support to theories that humans have a natural defense against Alzheimer’s that decreases with age. The study, IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline,” was a joint effort by researchers from the University of Glasgow, Scotland, U.K., andHong Kong University of Science and Technology (HKUST). It used a mouse model of Alzheimer’s called APP/PS1. These mice display both disease symptoms, such as cognitive decline, and the accumulation of amyloid-beta in their brains. Earlier studies have shown that patients with Alzheimer’s have low levels of IL-33, but researchers have not known what function the factor, that normally is particularly abundant in the central nervous system, plays in disease. "We found that injection of IL-33 into aged APP/PS1 mice rapidly improved their memory and cognitive function to that of the age-matched normal mice within a week," Eddy Liew, a University of Glasgow professor and one of the two senior researchers behind the study, said in a press release. IL-33 injections also reduced amyloid-beta plaques in the mice brains, a finding that the researchers showed was linked to an increased mobilization of microglia a
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